Femoflor and Androflor are molecular diagnostic tests (PCR) for assessing the condition and monitoring the health of the urinary and reproductive systems of women and men. By using these tests, it is possible to determine the qualitative and quantitative composition of the urogenital microflora made up of bacteria, fungi, and viruses. Unlike classic microbiological methods, Femoflor and Androflor tests can identify and determine the abundance of not only aerobic, but also anaerobic bacteria.
Femoflor and Androflor tests are based on the Real-Time PCR method, which is characterized by high specificity and sensitivity in the identification of microorganisms, but also by reducing subjectivity in the analysis of test results. Unlike classical microbiological methods, Real-Time PCR does not require strict conditions for storing and transporting the sample, which allows for greater convenience and simpler work in clinical practice, and the time from sampling to obtaining results is very short.
An exceptional advantage of using Femoflor and Androflor tests is the quantitative assessment of the composition of the genital microflora, based on which the balance between microorganisms is assessed. When microorganisms are present in a number and ratio that indicates balance, such a condition is called normocenosis. When the results of the Femoflor or Androflor test indicate disturbed relationships between the microorganisms that make up the genital microflora, such a condition is called dysbiosis and may require treatment with antibiotics, antifungals, or vaginal probiotics, as well as increased monitoring of the patient’s health by a doctor. It should also be borne in mind that Androflor and Femoflor provide the possibility of simultaneous qualification
in addition to quantification, so that in cases where quantitative assessment indicates dysbiosis, qualitative assessment simultaneously provides information about the bacteria, fungi, and viruses that are dominant in dysbiosis, which allows the doctor to make a better choice of therapy.
FEMOFLOR
In women, the microflora of the urogenital tract is of particular importance, as it has clear beneficial or harmful effects on women’s health. The ecology of the vaginal microflora, especially the high relative abundance of Lactobacillus spp., is considered crucial for the health of the urogenital tract, with an important role in the development of bacterial vaginosis (BV), but also an important role in preventing pathogen invasion and reducing susceptibility to gynecological infections, especially sexually transmitted infections (STIs).
Therefore, preventive FEMOFLOR testing is recommended, not only for pregnant women and women with an increased risk of infection, but also for every woman in order to detect changes in the vaginal microflora in a timely manner.
Femoflor® tests can be found in two variants:
trachomatis, Trichomonas vaginalis, Neisseria gonorrhoeae, Micoplasma genitalium, Cytomegalovirus, Herpes simplex virus 1, Herpes simplex virus 2, involved in the development of dysbiotic and pathological processes within the urogenital microbiocenosis.
Femoflor Screen enables the assessment of the microflora composition: urogenital normoflora – lactobacilli, obligately anaerobic microorganisms – Gardnerella vaginalis/Prevotella bivia/Porphiromonas spp., typical for the urogenital tract of women, mycoplasmas – Micoplasma hominis, Ureaplasma spp., fungi of the genus Candida.
mass (TBM) and concentration (absolute and relative) of the following species/genera of microorganisms:
Lactobacillus, Enterobacteriaceae, Streptococcus, Staphilococcus, Gardnerella vaginalis/Prevotella bivia/Porphirombacterium , Sneathia/Leptotrichia/ Fusobacterium, Megasphaera/Veillonella/Dialister, Lachnobacterium/Clostridium, Corinebacterium/Mobiluncus, Peptostreptococcus, Atopobium vaginae.
The ratio of these bacteria determines the state of the vaginal microflora – normocenosis or dysbiosis. Dysbiosis is assessed by the degree of severity (moderate or severe dysbiosis) and the dominance of aerobic or anaerobic conditionally pathogenic microflora (aerobic or anaerobic dysbiosis).
Only one sample of vaginal or cervical swab is required to perform this test.
Femoflor® is designed for the diagnosis of conditions such as vaginitis, cervicitis, predisposition to the development of sexually transmitted diseases, inflammation of the pelvic organs, infertility, spontaneous abortions, premature birth, and infections in neonates.
Timely, precise, and highly sensitive diagnostics with the aim of establishing a diagnosis is a prerequisite for correct and effective therapy. Probiotics with specific combinations of Lactobacilllus spp. are a good choice in the treatment of vaginal flora homeostasis disorders.
ANDROFLOR
The ANDROFLOR test enables the identification of the causative agent and the degree of microflora disorders in the urogenital tract of men, which is important for timely and effective treatment.
The Androflor test is recommended for patients who have the following symptoms: itching, burning, genital secretions, a feeling of discomfort and pain in the genitals, and urination disorders.
Also, the Androflor test is recommended in preparations for urological interventions and IVF procedures.
The Androflor test offers simultaneous, comprehensive diagnostics. The first part includes qualitative detection of pathogens of the urogenital tract of men (Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Micoplasma genitalium). The second part refers to the assessment of the composition of the microflora (a wide range of microorganisms that may be present in the urogenital tract of men as normocenosis, as well as causative agents of infectious and inflammatory diseases of the urogenital tract: Staphilococcus spp., Streptococcus spp., Corinebacterium spp., Lactobacillus spp., Gardnerella vaginalis, Atopobium cluster (Atopobium spp., Olsenella spp., Collinsella spp.), Megasphaera spp. /Veilonela spp. /Dialister spp., Sneathia spp./ Leptotrihia spp. / Fuso-bacterium spp., Ureaplasma urealyticum, Ureaplasma parvum, Micoplasma hominis, Bacteroides spp./Porphiromonas spp./Prevotella spp., Anaerococcus spp., Peptostreptococcus spp. / Parvimonas spp., Eubacterium spp., Pseudomonas aeruginosa / Ralstonia spp. / Burkholderia spp., Enterobacteriaceae family/ Enterococcus spp., Heamophilus spp., as well as fungi from the genus Candida spp.).
The samples are biological materials in the form of shavings of the epithelium from the balanus and urethra, the first stream of urine.
Femoflor and Androflor tests can be of exceptional importance in family planning. By combining these two tests and a comprehensive analysis of the results, a complete effect on the reproductive potential of both partners is achieved.
